Lab Journal Club: Synchronizing organ growth and developmental timing

CD_Fruitfly01This week we discussed four great papers from the Leopold, Halme, Gontijo (@alisson_gontijo) and Dominguez labs.

They all described how Lgr3 is the receptor for dILP8, a factor secreted from damaged organs to limit ecdysone release and slow organismal development and growth. While each paper made the same discovery, they did differ in experimental approaches and in some of their findings (which is not a bad thing).

All four were great papers – hopefully they receive the similar wide recognition that they each deserve.

Garelli A, Heredia F, Casimiro AP, Macedo A, Nunes C, Garcez M, Dias AR, Volonte YA, Uhlmann T, Caparros E, Koyama T, Gontijo AM. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Nat Commun. 2015 Oct 29;6:8732.

Colombani J, Andersen DS, Boulan L, Boone E, Romero N, Virolle V, Texada M, Léopold P. Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. Curr Biol. 2015 Oct 19;25(20):2723-9.

Vallejo DM, Juarez-Carreño S, Bolivar J, Morante J, Dominguez M. A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. Science. 2015 Nov 13;350(6262)

The relaxin receptor Lgr3 mediates growth coordination and developmental delay during Drosophila melanogaster imaginal disc regeneration. (2015) BioRxiv. Jacob S. Jaszczak, Jacob B. Wolpe, Rajan Bhandari, Rebecca G. Jaszczak, Adrian Halme