Lab Papers (click on journal for link)

  • Polan DM, Alansari M, Lee B, Grewal SS (2020) Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila. Biorxiv
  • Barretto EC, Polan DM, Beever-Potts AN, Lee B, Grewal SS (2019) FOXO mediates organismal hypoxia tolerance by regulate NF-kB in Drosophila BioRxiv
  • Lee B, Barretto EC, Grewal SS (2019) TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila. Nature Communications. 10, 1878
  • Sriskanthadevan-Pirahas S, Lee J, Grewal SS (2018)The EGF/Ras pathway controls growth in Drosophila via ribosomal RNA synthesis.  Dev Biol. 439(1):19-29
  • Sriskanthadevan-Pirahas S, Deshpande R, Lee B, and Grewal SS. (2018) Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila.  PLoS Genetics  Feb 5;14(2):e1007202
  • Deliu LP, Ghosh A, Grewal SS. (2017) Investigation of protein synthesis in Drosophila larvae using puromycin labelling.  Biol Open. 2017 Jun 22. pii: bio.026294
  • Rideout EJ, Narsaiya MS, Grewal SS. (2015) The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size. PLoS Genetics. 2015 Dec 28;11(12):e1005683
  • Grewal SS (2015) Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth. Biochim Biophys Acta
  • Ghosh A, Rideout EJ, Grewal SS (2014) ­­TIF-IA-dependent regulation of ribosome synthesis in Drosophila muscle is required to maintain systemic insulin signaling and larval growth. PloS Genetics 10(10):e1004750
  • Nagarajan S and Grewal SS (2014) An investigation of nutrient-dependent mRNA translation in Drosophila larvae. Biology Open, 3(11):1020-31
  • Killip LE and Grewal SS (2012) DREF controls tissue and organismal growth in Drosophila downstream of nutrition/TOR signaling. Developmental Biology 2012, 371, 191
  • Rodrigues AB, Ayala-Camargo A, Grewal SS, Reyes-Robles T, Krasny M, Wu DC, Johnston LA, and Bach E. Activated (2012) Stat is a supercompetitor that acts independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development 2012, 139, 4051
  • Grewal SS (2012) Controlling growth and body size – fruit fly physiology points the way. F1000 Reports 4:12
  • Marshall L, Rideout EJ, Grewal SS (2012) Nutrient-TOR dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J, 31:1916
  • Rideout EJ, Marshall L, Grewal SS. (2012) Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling Proc Natl Acad Sci U S A. 109(4):1139-44
  • Zielke N, Kim KJ, Tran V, Shibutani ST, Bravo MJ, Nagarajan S, van Straaten M, Woods B, von Dassow G, Rottig C, Lehner CF, Grewal SS, Duronio RJ, Edgar BA (2011) Control of Drosophila endocycles by E2F and CRL4CDT2. Nature, 480, 123.
  • Li L, Edgar B.A.E, Grewal S.S. (2010) Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biology. 11, 7
  • Grewal S.S. (2009) The insulin/TOR pathway in growth and homeostasis: A view from the fly world. Int J Biochem Cell Biol. 41, 1006.

From the Postdoc Years:

  • Grewal S.S., Evans, J and Edgar B.A. (2007)  Drosophila TIF-IA controls ribosome synthesis and cell growth, and is regulated by the TOR pathway. J. Cell Biol 179, 1105
  • Hall, D.J., Grewal, S.S., de la Cruz, A. and Edgar, B.A. (2007) Rheb and TOR regulate protein synthesis, but not bulk nutrient uptake, in Drosophila.  BMC Biology, 5, 10
  • Orian, A., Grewal, S.S., Knoepfler, P.S., Edgar, B.A., Parkhurst, S.M. and Eisenman, R.N. (2005) Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.  Cold Spring Harbor Symposium in Quantitative Biology, LXX, v.1.0.
  • Grewal, S.S , Li. L, Orian, A., Eisenman, R.N. and Edgar, B.A. (2005) Drosophila Myc regulates ribosomal RNA synthesis during development. Nat Cell Biol. 7: 295-302.
  • Grewal, S.S and Saucedo, L.J. (2004) Chewing the fat: regulating autophagy in DrosophilaDev Cell. 7:148-150
  • Grewal, S.S and Edgar, B.A. (2003) Controlling cell division in yeast and mammals: does size matter? J. Biol. 2: 5

From the PhD years (and before..)

  • Billiard, J., Grewal, S. S., Lukaesko, L., Stork, P. J., and Rotwein, P. (2001) Hormonal control of insulin-like growth factor I gene transcription in human osteoblasts: dual actions of cAMP-dependent protein kinase on CCAAT/enhancer-binding protein delta. J. Biol. Chem. 276: 31238-31246.
  • Grewal, S.S., Fass, D.M., Yao, H., Ellig, C.L., Goodman, R.H., and Stork, P.J. (2000) Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway. J. Biol. Chem. 275, 34433-34441.
  • York, R.D., Molliver, D.C., Grewal, S.S., Stenberg, P.E., McCleskey, E.W., and Stork, P.J. (2000) Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol. Cell. Biol. 20, 8069-8083.
  • Grewal, S.S., Horgan, A.M., York, R.D., Withers, G.S., Banker, G.A., and Stork, P.J. (2000) Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. J. Biol. Chem. 275, 3722-3728.
  • Grewal, S.S., York, R.D., and Stork, P.J. (1999) Extracellular-signal-regulated kinase signaling in neurons. Curr. Opin. Neurobiol. 9, 544-553.
  • Nakayama, T., Snyder, M.A., Grewal, S.S., Tsuneizumi, K., Tabata, T., and Christian, J.L. (1998) Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Development 125, 857-867.
  • Grewal, S.S., Shepherd, J.K., Bill, D.J., Fletcher, A., and Dourish, C.T. (1997) Behavioural and pharmacological characterization of the canopy stretched attend posture test as a model of anxiety in mice and rats. Psychopharmacology 133, 29-38.
  • Shepherd, J.K., Bill, D.J., Dourish, C.T., Grewal, S.S., McLenechan, A., and Stanhope, K.J. (1996) Effects of the selective angiotensin II receptor antagonists losartan and PD123177 in animal models of anxiety and memory. Psychopharmacology126, 206-218.
  • Shepherd, J.K., Grewal, S.S., Bill, D.J., Fletcher, A., and Dourish, C.T. (1994) Behavioural and pharmacological characterization of the elevated “zero-maze” as an animal model of anxiety. Psychopharmacology 116, 56-64.
  • Kennett, G.A., Wood, M.D., Glen, A., Grewal, S.S., Forbes, I., Gadre, A., and Blackburn, T.P. (1994) In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br. J. Pharmacol. 111, 797-802.